Arsenal will be without Gervinho and Alex Song, both of whom begin three-match bans.
Kieran Gibbs, Johan Djourou, Tomas Rosicky and Armand Traore are all ruled out through injury, while Jack Wilshere and Abou Diaby also remain sidelined.
Liverpool full-back Glen Johnson could return from the hamstring injury he picked up in pre-season.
Steven Gerrard is the only definite major absentee as he continues his rehabilitation from a groin problem.